The correct option is A CO2 concentration
Chemoreceptors that affect breathing rate are into two categories: central chemoreceptors: are located on the ventrolateral surface of medulla oblongata and detect changes in pH of cerebrospinal fluid. They respond to hypercapnic hypoxia - elevated CO2, decreased O2. Peripheral chemoreceptors: the aortic body detects changes in blood oxygen and carbon dioxide, but not pH, while the carotid body detects all three. Their effect on breathing rate is less than that of the central chemoreceptors.