Read the following statements and choose the correct option.
I. In phenylketonuria the affected person does not secrete the enzyme to convert phenylalanine to tyrosine
II. Possibility of male becoming haemophiliac is extremely rare
III. Sickle cell anaemia is caused by the substitution of glutamic acid by valine at fifth position of beta chain of haemoglobin
IV. Myotonic dystrophy is an autosomal dominant trait.