The correct option is C Decrease the affinity of hemoglobin with oxygen
The pH of blood reduces in the presence of carbon dioxide because carbon dioxide reacts with water to form carbonic acid.
High H+ concentration favours dissociation of oxyhaemoglobin. It shifts the oxygen dissociation curve towards the right. Hence the correct answer is that pH reduction decreases the affinity of haemoglobin with oxygen.
A lower pH of the blood increases carbon dioxide concentration which in turn, is suggestive of more utilisation of oxygen. According to Bohr, lower pH will cause haemoglobin to deliver more oxygen. This manifests as a rightward shift in the Oxygen-Hemoglobin Dissociation Curve described in oxygen transport and yields enhanced unloading of oxygen by haemoglobin.
Upon increase in carbon dioxide, the pH of blood reduces, resulting in hemoglobin proteins releasing their load of oxygen. Hence, it decreases the affinity of hemoglobin with oxygen.