Question

Refer the internet and find out how to make orally active protein pharmaceutical. What is the major problem to be encountered?

Answer 1

The major problem here is that the proteins with short half-lives are not orally active and are not absorbed properly. An orally active protein should be metabolically stable and have a longer half-life so that it is not degraded fast and should be absorbed efficiently.

To make orally active protein drug, the site directly mutagenesis can be used to redesign their genes for the expression of a modified peptide.