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Question

Refer to the given figure and answer the question.
Select the factors that are responsible for left shift of the oxygen dissociation curve:

I. Increase in pCO2
II. Decrease in temperature
III. Increase in pO2
IV. Decrease in H+ concentration
V. Increase in 2,3 DPG


A
I, II and III
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B
I, II, III and IV
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C
I and III
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D
II, III and IV
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Solution

The correct option is D II, III and IV
The given graph shows the oxygen – haemoglobin dissociation curve. The relationship between the pO2 and the percent saturation of haemoglobin when represented on a graph is termed as oxygen – haemoglobin dissociation curve. It is S-shaped because of the behaviour of the Hb in different pO2 . The factors that causes left shift on the graph are as follows:
I. Decrease in pCO2
II. Decrease in temperature
III. Increase in pO2
IV. Decrease in H+ concentration
V. Decrease in 2,3 DPG (2,3 Diphosphoglyceric acid)

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