Question

Refer to the given graph representing interplay of different hormones (A-D) during menstrual cycle in women and answer the questions that follow.
Cessation of secretion of which of these hormones may lead to osteoporosis?

• A. A
• B. B
• C. C
• D. D

Answer 1

The correct option is A A

A represents hormone estrogen. In old age, after menopause, almost no estrogens are secreted by the ovaries. This estrogen deficiency leads to (1) Increased osteoclastic activity in the bones, (2) deceased bone matrix, and (3) decreased deposition of bone calcium and phosphate. In some women, this effect is extremely severe, and the resulting condition is osteoporosis. Because this can greatly weaken the bones and lead to bone fracture; especially fracture of the vertebrae, a large share of postmenopausal women are treated prophylactically with estrogen replacement to prevent the osteoporotic effects.

So, the correct answer is 'A'.