Regarding the assertion and reason, choose the correct option.
Assertion [A]: A genetic disease that affects only one parent can have 50% chance of affecting the child.
Reason [R]: An autosomal dominant defective allele can cause a disease even in heterozygous condition.
Regarding the assertion and reason, choose the correct option.
Assertion [A]: A genetic disease that affects only one parent can have 50% chance of affecting the child.
Reason [R]: An autosomal dominant defective allele can cause a disease even in heterozygous condition.
The correct option is C Assertion [A] is True and Reason [R] is True and is a correct explanation for [A].
If a person has an autosomal dominant gene mutation, they do not have the ability to make enough of the correct gene product and will have symptoms of the genetic condition. Dominant inheritance means an abnormal gene from one parent can cause disease. A person needs to inherit only one affected copy of the gene pair in order to be affected with a specific autosomal dominant disorder. This affected copy or allele “dominates” the pair of genes, and expresses itself in the form of the disease. In an autosomal dominant disorder, a single allele from one parent can cause the child to have the disorder. A person with an autosomal dominant disorder has a 1 in 2 (50 percent) chance of passing on the affected allele, and a 1 in 2 (50 percent) chance of passing on the normal allele to each child. So, there is a 50-50 chance that each child of the affected person will inherit the disease. This 50-50 chance is the same with every pregnancy. The inheritance pattern is illustrated in the image below.
Assertion [A] is True and Reason [R] is True and is a correct explanation for [A].
If a person has an autosomal dominant gene mutation, they do not have the ability to make enough of the correct gene product and will have symptoms of the genetic condition. Dominant inheritance means an abnormal gene from one parent can cause disease. A person needs to inherit only one affected copy of the gene pair in order to be affected with a specific autosomal dominant disorder. This affected copy or allele “dominates” the pair of genes, and expresses itself in the form of the disease. In an autosomal dominant disorder, a single allele from one parent can cause the child to have the disorder. A person with an autosomal dominant disorder has a 1 in 2 (50 percent) chance of passing on the affected allele, and a 1 in 2 (50 percent) chance of passing on the normal allele to each child. So, there is a 50-50 chance that each child of the affected person will inherit the disease. This 50-50 chance is the same with every pregnancy. The inheritance pattern is illustrated in the image below.
