Question

Rejection of organ transplant is due to

• A. NK cells
• B. B-cells
• C. Cytotoxic T-cells
• D. Suppressor cells

Answer 1

The correct option is C Cytotoxic T-cells

Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Killer T cells, also called cytotoxic T lymphocytes (CTLs), have CD8 receptors that recognize the transplanted tissue's MHC (major histocompatibility complex) class I molecules, which display the donor's self-antigens. Thereupon, the T cell receptors (TCRs) of the killer T cells recognize their matching epitope and trigger the target cell's programmed cell death by apoptosis.

So, the correct answer is 'Cytotoxic T-cells'.