Question

Replacement of which one of the following nucleotides in the Hbb gene that codes for hemoglobin protein causes sickle cell anaemia?

• A. A to U
• B. C to G
• C. U to A
• D. T to A

Answer 1

The correct option is A A to U

Sickle cell anemia is a hereditary blood disorder characterized by an abnormality in haemoglobin molecule in the red blood cells. This is a disorder caused due to a point mutation in the ββ- globin chain of hemoglobin. There is a point mutation which replaces A by U and results in glutamic acid replaced by valine. This results in the formation of abnormal hemoglobin and sickle-shaped RBCs.

Thus, the correct answer is option A.