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Question

Secretin is secreted from

A
Endocrine gland and acts on an endocrine gland
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B
Exocrine gland and acts on an exocrine gland
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C
Endocrine gland and acts on an exocrine gland
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D
Exocrine gland and acts on an endocrine gland
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Solution

The correct option is C Endocrine gland and acts on an exocrine gland
  • Secretin is secreted from the endocrine gland and acts on an exocrine gland.
  • It is secreted by cells in the duodenum when they are exposed to the acidic contents of the emptying stomach.
  • It stimulates the exocrine portion of the pancreas to secrete bicarbonate into the pancreatic fluid.
  • When hydrochloric acid passes from the stomach into the duodenum, secretin is released into the bloodstream and stimulates the acinar cells of the pancreas to secrete water and bicarbonate into the pancreatic ducts that drain into the duodenum.
  • By this mechanism, hydrochloric acid secreted by the stomach, which can be damaging to the intestinal lining, is promptly diluted and neutralized.
  • Secretin also inhibits the secretion of gastrin, which triggers the initial release of hydrochloric acid into the stomach, and delays gastric emptying.
    Hence, option C is correct.

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