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Question

Secretion of which of the following substances is inhibited by low pH?

A
Secretin
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B
Gastrin
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C
CCK
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D
GIP
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Solution

The correct option is B Gastrin
Gastrin's principal physiological action is to increase H+ secretion. H+ secretion decreases the pH of the stomach contents. The decreased pH, in turn, inhibits further secretion of gastrin—a classic example of negative feedback.

Secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver.

Cholecystokinin plays a key role in helping digestion within the small intestine.

Gastric inhibitory polypeptide (GIP), or gastric inhibitory peptide, is an inhibiting hormone, its main role is to stimulate insulin secretion.

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