The correct option is
B. On
A preposition is a word which comes before a noun or a pronoun and establishes a relationship between the elements of a clause or words. Option B 'on' is correct as it is used to express an involvement in a particular activity. The other options are wrong as at, upon, against and with indicate a specific location, a surface above something, opposition and inclusion respectively. These uses don't fit in the given question. The correct answer is B 'on'.