Question

Select the correct combination of statements regarding myasthenia gravis.
I. It is an autoimmune disorder.
II. It causes insufficient acetylcholine binding that effects muscular contraction.
III. Antibodies are developed against acetylcholine.
IV. Antibodies are developed against acetylcholine receptors.
V. It causes drooping of eyelids.

• A. I, III, IV, V
• B. I, III, V, II
• C. I, II, IV, V
• D. II, III, IV, V

Answer 1

The correct option is C I, II, IV, V

Statements I, II, IV and V are correct.
Myasthermia gravis is an autoimmune neutromuscular disease that is cogenital. It leads to muscle weakness. It is caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction inhibiting the excitatory effects of acetylcholine and nicotic receptors at neuromuscular junctions. First noticeable symptom is weakening of eye muscle leading to drooping of eyelids.
It is treated medically with acetycholine esterase inhibitors or immuno suppressants.