Question

Select the correct combination of statements regarding the disease, myasthenia gravis.
(i) It is an autoimmune disorder.
(ii) It causes insufficient acetylcholine binding that affects muscular contraction.
(iii) Antibodies are developed against acetylcholine.
(iv) Antibodies are developed against acetylcholine receptors.
(v) Antibodies are developed against acetylcholine esterase.
(vi) It causes drooping of eyelids.

• A. (i), (iii), (iv), (vi)
• B. (i), (iii), (v), (vi)
• C. (i), (ii), (iv), (vi)
• D. (ii), (iii), (iv), (v)

Answer 1

The correct option is C (i), (ii), (iv), (vi)

Myasthenia gravis is an autoimmune disease. This disease caused to the neuromuscular junction, which is the contact point between nerves and muscles. When the acetylcholine binds to the receptors, it activates the muscles and causes a muscular contraction. The antibodies can block, alter, or destroy the acetylcholine receptors, thereby preventing the muscles from contracting. The muscles become weaker with time and are particularly vulnerable when undergoing continuous activity. One of the muscle groups that are often involved is the eyelid. The patients affected by this disease can be seen suffering from dropping of eyelids.

So, the correct answer is option C.