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Question

Select the correct sequence which represents the various stages of follicular development?

A
Primordial follicle → Graafian follicle → Secondary follicle → Tertiary follicle → Primary follicle
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B
Primordial follicle → Primary follicle → Graafiann follicle → Tertiary follicle → Graafian follicle
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C
Primordial follicle → Primary follicle → Secondary follicle → Tertiary follicle → Graafian follicle
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D
Graafian follicle → Primordial follicle → Secondary follicle → Tertiary follicle → Primary follicle
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Solution

The correct option is C Primordial follicle → Primary follicle → Secondary follicle → Tertiary follicle → Graafian follicle

The process of follicular development from primordial germ cells to Graafian follicle is called folliculogenesis. Primordial germ cells differentiate into oogonia and then after undergoing mitosis forms primary oocytes during the fetal stage.

Each primary oocyte gets covered by granulosa cells and grows into a large primary follicle.

When primary follicles get covered by many more layers of granulosa cells and the formation of a new theca (a layer of connective tissues that surrounds the granulosa cells) around it takes place, they are then called secondary follicles. Secondary follicles are larger than primary follicles.

Secondary follicles on further development transform into a tertiary follicle which is characterized by the fluid-filled cavity called the antrum.


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