Select the option which completes the given equation for reductive amination.

(I) -

α

- ketoglutaric acid, (II) - Transaminase

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(I) -

α

- ketoglutaric acid, (II) - Glutamate dehydrogenase

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(I) - Asparagine, (II) - Glutamate dehydrogenase

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(I) - Glutamate, (II) - Transaminase

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Solution

The correct option is B (I) - $α$ - ketoglutaric acid, (II) - Glutamate dehydrogenase
In this reaction, ammonia combines with a keto acid. The most important keto acid is the alpha ketoglutaric acid produced during the operation of Krebs cycle. The keto acid then undergoes enzymatic reductive amination to produce an amino acid. The enzyme is glutamate dehydrogenase.
Thus, the correct answer is 'i-alpha-ketoglutaric acit, ii- glutamate dehdrogenase.'

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It represents

Refer to the given reaction.

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Refer to the given reaction.

a -Ketoglutaric acid + $N H_{4}^{+}$ + NADPH $G l u t a m a t e - -------- \to d e h y d r o g e n a s e G l u t a m a t e + H_{2} O + N A D P$

It represents

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C O_{2}

\begin{matrix} I . C i t r i c a c i d & \to & α - k e t o g l u t a r i c a c i d I I . S u c c i n i c a c i d & \to & M a l i c a c i d I I I . M a l i c a c i d & \to & O x a l o a c e t i c a c i d I V . α - k e t o g l u t a r i c a c i d & \to & S u c c i n y l C o - A \end{matrix}

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