Question

Select the option which is not correct with respect to enzyme action.

• A. Addition of lot of succinate does not reverse inhibition of succinic dehydrogenase by malonate
• B. A non-competitive inhibitor binds the enzyme at a sight distinct from that which binds the substrate
• C. Malonate is a competitive inhibitor of succinic dehydrogenase
• D. Substrate binds with the enzyme at its active site

Answer 1

The correct option is A Addition of lot of succinate does not reverse inhibition of succinic dehydrogenase by malonate

Succinate dehydrogenase is an enzyme which is present in the inner mitochondrial membrane. It catalyzes the oxidation of succinate to fumarate. It is a conjugated protein as it has flavoprotein which has FMN or FAD molecule as a prosthetic group. Malonate acts as an inhibitor which competes with the succinate and prevents its attachment to the enzyme. Succinate is a substrate so its addition does not reverse the inhibition of succinic dehydrogenase by malonate.

So, the correct answer is option A.