Semi-conservative replication of DNA was first demonstrated in

Drosophila melanogaster

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Escherichia coli

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Streptococcus pneumoniae

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Salmonella typhimurium

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Solution

The correct option is D Escherichia coli
Some of the major experimental proofs that DNA replication is semi-conservative, they are as follows:
1. Meselson and Stahl experiment
2. Taylor’s experiment
The experiment carried out by Mathew Messelson and Franklin Stahl (1957-58) conclusively proved that in intact living E. coli cells the DNA is replicated by semi-conservative manner as postulated by Watson and Crick
J.H. Taylor et. al. (1958) also demonstrated the semi-conservative mode of replication in DNA and chromosomes in root tip cells of Vicia faba
So, the correct answer is 'Escherichia coli'

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