Question

Set of healthcare products are given. Match them with organisms which are genetically engineered for that respective product.

Answer 1

Insulin - Humulin through Escherichia colI

Somatotropin - hGH in Escherichia coli

Interferon - Escherichia coli or Saccharomyces

Interleukins - Escherichia coli or yeast

Humulin is synthetic human insulin prepared by using genetic engineering. Humulin is manufactured from DNA sources in laboratory, using recombinant DNA technology. Synthetic insulin is also called genetically engineered insulin. The synthetic insulin (humulin) is as effective as hormone insulin secreted by human pancreas.

Somatotropin is growth hormone. It is artificially produced by recombinant DNA technology. Produced by the pituitary gland, human growth hormone (HGH) is essential for proper growth in children. Some children, however, have disorders that cause reduced HGH levels. If children go without treatment, they mature as unusually short adults. This condition is treated by administering HGH, which today is produced by using recombinant DNA (rDNA) technology

Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response.

Recombinant interferon refers to interferon compounds that are produced by recombinant techniques. In recombinant technology, a gene of interest is placed into the genome of a system, such as a cell culture or a specific animal, in which manipulation can lead to increased production of the gene product of interest. The final protein product is then isolated and used for its intended purposes.

The ability of interferons to help the body’s immune response means that recombinant interferon is used to treat many human diseases that involve abnormal immune function. Using recombinant interferon is therefore often referred to as immunotherapy. Recombinant interferon can be used to treat a variety of conditions, including specific cancers or leukemias, HIV-associated disorders, warts, and hepatitis. Recombinant interferon does not actually kill the aberrant cells or pathogens on its own, but rather induces the immune system to do so.

Interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells. Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation. Recombinant interleukins are produced with the help of E.coli or yeast.