Sickle-cell anaemia is

caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

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caused by a change in a single base pair of DNA

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characterized by elongated sickle like RBCs with a nucleus

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an autosomal linked dominant trait

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Solution

The correct option is B caused by a change in a single base pair of DNA
Sickle-cell anaemia is an autosomal- linked recessive hereditary disorder in which erythrocytes become sickle shaped with no nucleus in it. It is caused by a change in a single base pair of DNA which codes for beta globin chains. In the beta globin m-RNA gene, there is single base substitution at the 6th codon from GAG to GUG. This results in substitution of glutamic acid (Glu) by valine (Val) at the 6th position of the beta globin chain of the haemoglobin molecule.

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