Question

Sickle-cell anaemia is

Answer 1

Sickle-cell anaemia is an autosomal- linked recessive hereditary disorder in which erythrocytes become sickle shaped with no nucleus in it. It is caused by a change in a single base pair of DNA which codes for beta globin chains. In the beta globin m-RNA gene, there is single base substitution at the 6th codon from GAG to GUG. This results in substitution of glutamic acid (Glu) by valine (Val) at the 6th position of the beta globin chain of the haemoglobin molecule.