Question

Sickle cell anaemia is a disorder caused due to change in chemical nature of

• A. $\alpha$-chain of haemoglobin
• B. $\beta$-chain of haemoglobin
• C. Plasma protein
• D. Both $\alpha$ and $\beta$-chains of haemoglobin

Answer 1

Answer: (B)

$\beta$-chain of haemoglobin

Sickle-cell anaemia is caused by a point mutation in the β-globin chain of haemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position. The β-globin gene is found on the short arm of chromosome 11.

So, the correct answer is 'β-chain of haemoglobin'.