Question

Sickle-cell anaemia is caused due to the substitution of

• A. Valine at the 6th position of alpha globin chain by glutamic acid
• B. Glutamic acid at the 6th position of beta globin chain by valine
• C. Valine at the 6th position of beta globin chain by glutamine
• D. Glycine at the 6th position of alpha globin chain by glutamic acid

Answer 1

The correct option is B Glutamic acid at the 6th position of beta globin chain by valine

Sickle-cell anemia is caused by the single base substitution of Glutamic Acid (Glu) by valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule. It is an autosomal-linked recessive trait that can be transmitted from parents to the offsprings when both the parents are the carrier of the disease.