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Question

Sickle-cell anaemia is caused due to the substitution of by at the sixth position.

A
glutamic acid
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B
valine
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C
glutamine
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D
glycine
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Solution

The correct options are
A glutamic acid
B valine
Sickle-cell anaemia is a genetic disorder in which the RBCs become sickle-shaped under oxygen deficiency. It is caused by the replacement of glutamic acid by valine at the sixth position. These sickle shaped cells cannot pass through the narrow capillaries, thereby reducing the amount of oxygen transported.

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