Sickle cell anaemia is more common in South Africa. This is due to

Change in beta-chain of haemoglobin

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Change in alpha-chain of haemoglobin

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Change in gamma-chain of haemoglobin

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Change in beta-chain of haemoglobin

Sickle cell anaemia is a disorder of the blood caused by an inherited abnormal hemoglobin. The abnormal hemoglobin causes distorted (sickled) red blood cells. Sickle cell anaemia is caused by a single gene mutation in the sixth place of the β− chain of haemoglobin where glutamic acid is replaced by valine.

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β

In sickle cell anaemia, there is a change in the amino acid in the beta chain at position:

Beta globin chain of haemoglobin becomes abnormal in

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