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Question

Sickle cell anaemia is

A
An autosomal linked dominant trait
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B
Caused by substitution of valine by glutamic acid in the β-globin chain of haemoglobin
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C
Caused by a change in base pair of DNA
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D
Characterized by elongated sickle like RBCs with a nucleus
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Solution

The correct option is A Caused by substitution of valine by glutamic acid in the β-globin chain of haemoglobin
Sickle-cell anaemia is caused by a change in a single base pair of DNA (substitution of valine by glutamic acid in the β-globin chain of haemoglobin). It is a genetic disease. The individuals suffering from sickle-cell anaemia are immune to malaria. Thus, option B is correct.

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