Sickle cell anaemia results due to mutation caused by
A
Substitution
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B
Insertion
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C
Deletion
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D
Duplication
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Solution
The correct option is B Substitution The mutation causing sickle cell anemia is a single nucleotide substitution (A to T) in the codon for amino acid 6. The change converts a glutamic acid codon (GAG) to a valine codon (GTG).