Indus valley civilization was located in the northwestern part of the Indian subcontinent. The Mesopotamian civilization was located in present day Iraq.
Important river of the Indus valley civilization was the Indus river. Important river of the Mesopotamian civilization was the Tigris and the Euphrates.
Indus valley civilization existed from about 3300 BCE to 1300 BCE. Mesopotamian civilization existed from about 4000 BCE to 539 BCE.
Some inventions of the Indus valley civilization were buttons, rulers and stepwells. Inventions of the Mesopotamian civilization were chariots, plougs, sailboat etc.