Question

Spindle formation can be disrupted by exposing cell to the microtubule poison such as

• A. high concentration of oxygen
• B. Vitamin A
• C. cholesterol
• D. colchicine

Answer 1

Answer: (D)

colchicine

Chromosome separation takes place during the anaphase of mitosis where is cell gets half of the chromosome that results in an equational division. When a mitotic inhibitor such as colchicine is introduced it affects the microtubule formation and thus the spindle formation.

So, such cell gets stuck at the metaphase stage where the chromosome cannot split and the resulting daughter cell have more number of chromosome then it should which results in the polyploidy.

So, the correct option is 'colchicine'