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Question

Spleen increases in size during malaria due to

A
More lymphocytes
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B
Dead RBC
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C
Antibodies
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D
Both A and B
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Solution

The correct option is B Dead RBC
The infected or ruptured RBCs by the malarial parasite are caught up by the spleen and a marked immunological response occurs. The spleen subsequently becomes very congested, soft and starts to increase in size. This occurs more commonly in non-immune individuals and can lead to spontaneous rupture of the spleen. The splenic sinusoids become enlarged due to both hyperplasia and hypertrophy of the specialized splenic macrophages.
Thus, the correct answer is option B.

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