Question

Statement 1: Genetic disorder caused by change in the molecular structure of haemoglobin is sickle cell anaemia.

Statement 2: It results in the production of sickle-shaped WBC.

• A. Statement 1 is true and statement 2 is false
• B. Statement 1 is false and statement 2 is true
• C. Both the statements are false
• D. Both the statements are true

Answer 1

The correct option is A Statement 1 is true and statement 2 is false

Sickle-cell anaemia is a genetic disorder. It arises due to the replacement of glutamic acid by valine at the sixth position of the haemoglobin chain. As a result, the shape of the RBC changes to sickle-shaped from biconcave. These RBCs cannot pass through the blood vessels and have a tendency to clot, resulting in anaemia. Clogged blood vessels reduces blood circulation due to which tissues becomes deprived of oxygen.