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Chromatography is the technique used for the separation of those solutes that dissolve in the same solvent. In this technique, the difference in the rate of movement of the solute particles is used to separate them.
The solubility of the component is directly related to the ability of the component to move up. The component with the higher solubility will migrate to the top of the paper compared to other
components with less solubility. Hence, the solubility of the components of the mixture affects the process of chromatography as the higher the solubility of solute, the faster the components will elute out of the solvent.