The activity of a certain protein is dependent on its phosphorylation. A mutation in its gene changed a single amino acid which affected the function of molecule. Which amino acid change is most likely to account for this observation?

Tyrosine to Tryptophan

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Lysine to valine

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Leucine to isoleucine

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Valine to alanine

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Solution

The correct option is A Tyrosine to Tryptophan
Tyrosine is the amino acid which is involved in phosphorylation. If there is a mutation in the gene of the single amino acid tyrosine, there will be no phosphorylation observed and the protein will not attain its functionality. So, the mutation which will change the amino acid tyrosine to tryptophan will cause the protein to lose its function.
Thus, the correct answer is option A.

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