Question

The antisense strand of a fragment of DNA is AGGTATCCCAT. What will be the corresponding sequence of the antisense strand of mRNA?

• A. AGGUAUCCCAU
• B. UGGTUTCGCAT
• C. ACCUAUGCGAU
• D. UCCAUAGCGUA

Answer 1

The correct option is A AGGUAUCCCAU

DNA normally has two strands, i.e., the sense strand and the antisense strand. In double-stranded DNA, only one strand codes for the mRNA which, in turn, is translated into protein. This template DNA strand is referred to as the antisense strand. The strand that does not code for RNA is called the sense strand/coding strand. It is not used in transcription because it corresponds to the same sequence of the mRNA.

The antisense strand of a fragment of DNA is AGGTATCCCAT. The mRNA sequence transcribed from this strand is UCCAUAGGGUA. Now, a strand can be synthesised complementary to this strand for various purposes will be considered as the antisense strand of mRNA (antisense RNA)- AGGUAUCCCAU. This complementary antisense RNA can hybridise with the mRNA and block its translation into protein.