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Question

The blood-testis barrier is formed by


A
spermatogonia
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B
spermatids
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C
Sertoli cells
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D
Leydig cells
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Solution

The correct option is C Sertoli cells
Spermatogenesis occurs in the seminiferous tubules. This includes the growth and multiplication phase by mitosis and meiosis to form haploid gametes, followed by maturation to form spermatocytes. Each seminiferous tubule is lined by two kinds of cells- spermatogenic cells which eventually form the sperms and Sertoli cells or nurse cells which nourishes the developing spermatogenic cells and provide them with nutrition especially the spermatids.

Sertoli cells are epithelial supporting cells of the seminiferous tubules. They are derived from the epithelial sex cords of the developing gonads. Sertoli cells are connected to each other by continuous tight junctions that seal the tubules into two compartments- the basal(close to the basal lamina) and the adluminal (towards the lumen) compartment.

The blood-testis barrier is formed between Sertoli cells of the seminiferous tubule and it helps to isolate the further developed stages of germ cells from the blood, that is why it can also be called the Sertoli cell barrier.

Spermatogonia are present on the inside wall of the seminiferous tubule, formed by repeated mitotic division of the primordial germ cells.
The haploid cells produced after the second round of maturation division in the process of spermatogenesis are spermatids.
The interstitial space contains clumps of darker eosinophilic cells which produce and release testosterone are interstitial or Leydig’s cells.

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