The Cahn-Ingold-Prelog (CIP) priorities of the groups and the absolute configuration (R/S) of the following compound are:
A
CH2OH>CH(CH3)2>CH=CH2>CH3andS
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B
CH2OH>CH=CH2>CH(CH3)2>CH3andS
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C
CH2OH>CH=CH2>CH(CH3)2>CH3andR
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D
CH2OH>CH(CH3)2>CH=CH2>CH3andR
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Solution
The correct option is BCH2OH>CH=CH2>CH(CH3)2>CH3andS According to CIP rule the priorities of the groups are CH2OH>CH=CH2>CH(CH3)2>CH3
Here the counting of substituents from 1 to 3 is anticlockwise keeping the lowest priority group below the plane. So, the absolute configuration of the given compound is ‘S’.