The cell is not allowed to past the cell cycle restriction point, DNA damage is detected. Which of the following proteins are involved in detection of DNA damage and inhibition of cycle at the restriction point?
The cell is not allowed to past the cell cycle restriction point, DNA damage is detected. Which of the following proteins are involved in detection of DNA damage and inhibition of cycle at the restriction point?
The correct option is C Replication protein A (RPA)
A. Replication protein (RPA) - is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. ... During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures.
B. ATM (ataxia telangiectasia mutated ) protein
It activates checkpoint signalling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.
C.Cyclin D - a member of the cyclin protein family that is involved in regulating cell cycle progression.
D.PSS - an autoimmune disease of the connective tissue. It is characterized by thickening of the skin caused by the accumulation of collagen, and by injuries to small arteries.
So, the correct option is ‘Replication protein A (RPA)’.
A. Replication protein (RPA) - is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. ... During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures.
B. ATM (ataxia telangiectasia mutated ) protein
It activates checkpoint signalling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.
C.Cyclin D - a member of the cyclin protein family that is involved in regulating cell cycle progression.
D.PSS - an autoimmune disease of the connective tissue. It is characterized by thickening of the skin caused by the accumulation of collagen, and by injuries to small arteries.
So, the correct option is ‘Replication protein A (RPA)’.
