The 'Christmas disease' patient lacks antihaemophilic
Hemophilia is an inherited bleeding disorder characterized by lacking or low levels of clotting factors resulting in the inability or impaired ability of blood clotting. Hemophilia A is caused by a deficiency of clotting factor VIII. Hemophilia B is also known as Christmas disease and is caused by a deficiency of clotting factor IX. Hemophilia C is caused by a deficiency of Factor XI blood clotting factor. Alkaptonuria is a genetic disorder which imparts inability to process the amino acids phenylalanine and tyrosine. Mutation in the HGD gene that codes for the enzyme homogentisate 1,2-dioxygenase is the cause of this disorder. A person homozygous for mutated allele accumulates an intermediate substance called homogentisic acid in the blood and tissues. The correct answer is "D".