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Features of Codon

The codon on ...

Question

The codon on mRNA are CAU-CCU-AAA-CUG.
Identify the correct sequence of amino acid

A

H i s - P r o - L y s - L e u

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B

P r o - H i s - L y s - L e u

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C

H i s - P r o - L e u - L y s

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D

P r o - L e u - L y s - H i s

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Solution

The correct option is A $H i s - P r o - L y s - L e u$
The correct sequence of amino acids is CAU-Histidine,CCU-Proline,AAA-Lysine,CUG-Leucine
So, the correct answer is 'His−Pro−Lys−Leu'

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A relevant portion of

β

-chain of haemoglobin of a normal human is
Val-His-Leu-Thr-Pro-Glu-Glu
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The codon for the sixth amino acid is GAG. It mutates to GAA due to mutation 'A' and GUG due to mutation 'B'. Haemoglobin structure did not change as a result of mutation 'A' but mutation 'B' led to sickle cell-shaped RBCs. Explain giving reasons how could mutation 'B' change the haemoglobin structure and not mutation 'A'.

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Q. In an in vitro translation experiment, poly(UC) RNA template produced poly(Ser-Leu), while poly(AG) RNA template produced poly (Arg-Glu) polypeptide. Which one of the following options represents correct interpretations of the codons assignments for Ser, Leu, Arg, and Glu.

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