The correct option is D −180
[x2−(x+2)]6=[(x+2)−x2]6=6∑r=06Cr(−1)r(x+2)6−r(x2)r
To get x4 in the expansion, r can take values 0,1,2 only.
So, consider 6C0(x+2)6−6C1(x+2)5(x2)+6C2(x+2)4(x2)2
Coefficient of x4
=6C0⋅6C2⋅22−6C1⋅5C3⋅23+6C2⋅24=60−480+240=−180