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Question

The cofactor for the enzyme carboxypeptidase is

A
copper
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B
iron
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C
zinc
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D
manganese
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Solution

The correct option is C zinc
An enzyme consists of a protein part called apoenzyme and non-protein part called cofactor. The apoenzyme and cofactor together forms the holoenzyme.

There are three kinds of cofactors - prosthetic groups, coenzymes and metal ions.

The non-protein but organic part which is permanently attached to the enzyme is called the prosthetic group. Example: Haem in peroxidase.

The coenzymes are transient organic groups which are not attached to the apoenzyme permanently like the prosthetic group. Example: NADP.

Metal ions are the inorganic cofactors which form coordination bonds with side chains at the active site. Example: Zinc in carboxypeptidase.

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