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Question

The correct order of nucleophilic-addition elimination reaction is

A

Amide > Ester > Acid anhydride > Acyl chloride

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B

Ester > Acid anhydride > Amide > Acyl chloride

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C

Acyl chloride > Acid anhydride > Ester > Amide

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D

Acid anhydride > Acyl chloride > Ester > Amide

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Solution

The correct option is C
Acyl chloride > Acid anhydride > Ester > Amide

Reactivity of Nucleephilic addition Elimination is deterimed by the leaving group ability. Weak bases are better leaving groups than strong bases.

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