The correct statement(s) about the stability of double helix is(are): 1. presence of hydrogen bonds 2. presence of hydrophobic interaction 3. presence of hydrophilic interaction 4. vander waal force
A
1 only
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B
1, 2 only
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C
1, 2, 3 only
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D
1, 2 3 and 4
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Solution
The correct option is B 1, 2 only The stability of double helix is due to the presence of hydrogen bond which involves hydrophobic interaction. The stability of the DNA double helix depends on a fine balance of interactions including hydrogen bonds between bases and surrounding water molecules, and base-stacking interactions between adjacent bases.
The heterocyclic bases of single-stranded DNA have polar amido, amidino, guanidino and carbonyl groups that form a complex network of hydrogen bonds with the surrounding water molecules.
Some of these bonds must be broken during duplex formation as the inter-base hydrogen bonds are formed.