The correct option is D Thyroxine
Since thyroxine stimulates the basal metabolic rate, a deficiency of thyroxine results in lowering of the metabolic rate, some of the consequences of which are an increase in the body weight and a somewhat swollen face.
Calcitonin stimulates the deposition of calcium ions in bones, so its deficiency causes bone degradation.
Melatonin regulates the diurnal cycle of the body, so its deficiency disrupts patterns of sleep-wakefulness, hunger, etc.
MSH (melanocyte stimulating hormone) regulates pigmentation of the skin. The effects of its deficiency is not well-defined in human beings.