72
Question
The disease sickle-cell anaemia is caused by the substitution of (i) by (ii) at the (iii) position of (iv) globin chain of haemoglobin molecule.
Which of the, following correctly fills the blanks in the above statement?
Which of the, following correctly fills the blanks in the above statement?
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Solution
The correct option is D (i) glutamic acid, (ii) valine, (iii) sixth, (iv) beta
Haemoglobin is made of four polypeptide chains two
α-chains which are 141 amino acid long and two β-chains
which are 146 amino acids long. Sickle cell anaemia is due
to inheritance of a defective allele coding for β-globin. It
results in the transformation of HbA into Hbs in which
glutamic acid (Glu) is replaced by valine (Val) at sixth position in
each of two β globin chain of haemoglobin. The substitution of
amino acid in the globin protein results due to the single
base substitution at the sixth codon of the beta globin gene from GAG to
GUG.So, the correct answer is '(i) glutamic acid, (ii) valine, (iii) sixth, (iv) beta'.
Haemoglobin is made of four polypeptide chains two
α-chains which are 141 amino acid long and two β-chains
which are 146 amino acids long. Sickle cell anaemia is due
to inheritance of a defective allele coding for β-globin. It
results in the transformation of HbA into Hbs in which
glutamic acid (Glu) is replaced by valine (Val) at sixth position in
each of two β globin chain of haemoglobin. The substitution of
amino acid in the globin protein results due to the single
base substitution at the sixth codon of the beta globin gene from GAG to
GUG.
So, the correct answer is '(i) glutamic acid, (ii) valine, (iii) sixth, (iv) beta'.
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