Question

The enzyme hexokinase which catalysis glucose to a glucose-6-phosphate in glycolysis is inhibited by glucose-6-phosphate. This is an example of
I. Competitive inhibition
II. Non-competitive inhibition
III. Feedback allosteric inhibition
Which of the above statements is/are correct?

• A. I and II
• B. I and III
• C. Only Ill
• D. All of the above

Answer 1

The correct option is C Only Ill

Feedback inhibition is a form of allosteric regulation. There is an accumulation of the final product. This product goes and binds to the allosteric site of the enzyme and inhibits its activity. This type of mechanism is observed in the case of hexokinase. The enzyme converts the glucose to glucose-6-phosphate. The enzyme is inhibited by the accumulation of final product glucose-6-phosphate.

Thus, the correct answer is option C.