The correct option is E Reverse transcriptase
HIV is RNA retrovirus and synthesizes DNA using their RNA as a template via reverse transcription; a process carried out by reverse transcriptase enzyme. The synthesized DNA, cDNA, is inserted into a host and transcribed into RNA which in turn is translated into polypeptides. DNA polymerase, ligase, primase, and helicase are enzymes of DNA replication. Thus, the correct answer is option E.