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Question

The following pedigree chart is regarding a particular Mendelian disorder. Select the correct option regarding the disorder and genotype of the particular individual taken into consideration?
[0.7 mark]


A
Colour blindness; F2(III)XCXorXX
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B
Sickle cell anaemia; F1(V)Aa
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C
Haemophilia; F1(VI)XhXh
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D
Phenylketonuria; F1(II)Aa orAA
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Solution

The correct option is B Sickle cell anaemia; F1(V)Aa
The disorder cannot be X-linked because the girl child in F2 (IV) is affected but her father is normal. Similar case is seen for the child F2(I).

If we consider the parents F1(I,II) which are unaffected, one of their children is affected. So, the character should be autosomal recessive and the parents of this children are heterozygous.
For the affected child F2(IV), her father should be heterozygous. In this way the considered disorder can be sickle cell anaemia and F1(V) would be heterozygous that is Aa. Hence. correct option is b.

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