The genes which upon activation produce malignant neoplasms are called-

Pleiotropic genes

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Multiple genes

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Neonatal genes

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Proto-Oncogenes

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Solution

The correct option is D Proto-Oncogenes
Proto-oncogene is a normal gene which, when altered by mutation, becomes an oncogene that can contribute to cancer. Proto-oncogenes may have many different functions in the cell.
Pleiotropic genes are the genes which control more than one trait.
Neonatal genes are those which are present in neonates.

So, the correct answer is- Proto-oncogenes.

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