Question

The genetic defect adenosine deaminase (ADA) deficiency may be cured permanently by ___________.

• A. Introducing bone marrow cells producing (ADA) into cells at an early embryonic stage.
• B. Administrating adenosine deaminase activators.
• C. Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.
• D. Enzyme replacement therapy.

Answer 1

The correct option is A Introducing bone marrow cells producing (ADA) into cells at an early embryonic stage.

Adenosine deaminase deficiency (ADA deficiency) is an inherited condition that damages the immune system and is a common cause of severe combined immunodeficiency (SCID). People with SCID due to ADA deficiency are unable to fight off most types of infections, including bacterial, viral and fungal infections. Introduction of genes isolated from bone marrow cells, it produces ADA, into the cells of the patient at early embryonic stage. It can only cure permanently with the help of gene therapy.

So the correct answer is option A.